[81] Life cycle of magnetic nanoparticles in stem cells evidences an intracellular biosynthesis from degradation products V an de Walle, A. B.; Plan Sangnier, A.; Abou-Hassan, A.; Curcio, A.; Hémadi, M.; Lalatonne, Y.; Luciani, N.; Wilhelm, C. Proceedings of the National Academy of Sciences doi/10.1073/pnas.1816792116, 2019.
[80] Iron oxide nanochains coated with silica: synthesis, surface effects and magnetic properties. M Tadic, S. Kraljb, Y Lalatonne, L. Motte, Applied Surface Science, 476, 641-64, 2019.
[79] Targeted thermal therapy with genetically engineered magnetite magnetosomes@RGD: Photothermia is far more efficient than magnetic hyperthermia. Plan Sangnier, A.; Preveral, S.; Curcio, A.; K. A. Silva, A.; Lefèvre, C. T.; Pignol, D.; Lalatonne, Y.; Wilhelm, C. Journal of Controlled Release 279, 271-281, 2018.
[78] Tolerogenic Iron Oxide Nanoparticles in Type 1 Diabetes: Biodistribution and Pharmacokinetics Studies in Nonobese Diabetic Mice. C. Dubreil, O. S. Catherine, Y. Lalatonne, C. Journé, P. Ou, P. van Endert, L. Motte, Small, 14, 1802053, 2018
[77] Hybrid Au@alendronate nanoparticles as dual chemo-photothermal agent for combined cancer treatment. A. Plan Sangnier, R. Aufaure, L. Motte, C. Wilhelm, E. Guenin, Y. Lalatonne, Beilstein J. Nanotechnol., 9, 2947–2952, 2018.
[76] Nanohybrids with Magnetic and Persistent Luminescence Properties for Cell Labeling, Tracking, In Vivo Real-Time Imaging, and Magnetic Vectorization. E.Teston, T. Maldiney, I. Marangon, J. Volatron, Y. Lalatonne, L. Motte, C. Boisson-Vidal, G. Autret, O. Clément, D. Scherman, F. Gazeau, C. Richard, Small, 14, 1800020, 2018
[75] Palladium-Loaded Cucurbit[7]uril-Modified Iron Oxide Nanoparticles for C@C Cross-Coupling Reactions. F. Benyettou, L. Motte, H. Traboulsi, J.Mazher, R. Pasricha, J.-Carl Olsen, A. Trabolsi, E. Guenin, Chem. Eur. J., 24, 2349 – 2353, 2018
[74] Fabrication and Characterization of PZN-4.5PT Inorganic Perovskites Nanoparticles Thin Films Deposited on P-Type Silicon Substrate, R.Ndioukane, M. Touré, D. Kobor, L. Motte, M. Pasquinelli, Je.Solard, Journal of Modern Physics, 9, 259-272, 2018
[73] Selective growth inhibition of cancer cells with doxorubicin-loaded CB[7]-modified iron-oxide nanoparticles F. Benyettou, H. Fahs, R. Elkharrag, R. A. Bilbeisi,a B. Asma, R. Rezgui, L. Motte, M. Magzoub, J. Brandel, J.-C. Olsen, F. Piano, K. C. Gunsalus, C. Platas-Iglesias and A. Trabolsi, RSC Adv., 7, 23827-23834, 2017
[72] Versatile “click” synthesis of 1-hydroxy-1,1- methylenebisphosphonic acids with thioalkoxy substituents for the preparation of stable gold nanoparticles Aufaure, R., R. Buendia, L. Motte, J. Hardouin, Y. Lalatonne and E. Guénin, New J. Chem., 2017, 2017, 41, 12153-12158.
[71] Synthesis of metastable hard-magnetic ε-Fe2O3 nanoparticles from silica-coated akaganeite nanorods. M. Tadic, I. Milosevic, S. Kralj, M. Mitric, D. Makovec, M.-L. Saboungi and L. Motte. Nanoscale, 9, 10579-10584, 2017
[70] Synthetic melanin bound to subunit vaccine antigens significantly enhances CD8+ T-cell responses A. F. Carpentier, F. Geinguenaud, T.Tran, F. Sejalon, A. Martin, L. Motte, E. Tartour, C. Banissi, PLoS ONE 12(7): e0181403, , 2017
[69] Optimization of pegylated iron oxide nanoplatforms for Antibody coupling and bio-targeting. S. Richard, M. Boucher, A.Saric, A. Herbet, Y.Lalatonne, P. X. Petit, S. Mériaux, D. Boquet, L. Motte, J. Mater. Chem. B, 5, 2896-2907, 2017
[68] Iron oxide nanoparticle surface decorated with cRGD peptides for magnetic resonance imaging of brain tumors. S. Richard, M. Boucher, Y.Lalatonne, S. Mériaux, L. Motte. Biochim Biophys Acta. 1861 (6): 1515-1520, 2017
[67] Effects of coating spherical iron oxide nanoparticles. I. Milosevic, L. Motte, B. Aoun, T. Li, Y. Ren, C. Sun, M-L. Saboungi, Biochim Biophys Acta.;1861, 3621-3626, 2017.
[66] Poly(γ-glutamic acid) and poly(γ-glutamic acid)-based nanocomplexes enhance type II collagen production in intervertebral disc. Antunes, J. C., Leite Pereira, C., Silva, R. V., Caldeira, J., Grad, S., Gonçalves, R. M., Barbosa, M. A.. J. Mater. Sci: Mater. Med. 28, 6, 2017.
[65] Anti-oxidative theranostic iron oxide nanoparticles towards brain tumors imaging and ROS production. S. Richard, A. Saric, M. Boucher, C. Slomianny, F. Geffroy, S. Mériaux, Y.Lalatonne, P. X. Petit, L. Motte. ACS Chem. Biol. 11(10):2812-2819, 2016
[64] Tetrazine click chemistry for the modification of 1-Hydroxy-1,1-methylenebisphosphonic acids: towards bio-orthogonal functionalization of gold nanoparticles. R. Aufaure, J. Hardouin, N. Millot, L. Motte, Y. Lalatonne, E. Guénin, Chem. Eur. J., 22, 16022 – 16027, 2016.
[63] USPIO size controlled through microwave non-aqueous sol-gel method for neo-angiogenesis T2 MRI contrast agent. method for Ischemia T2 MRI contrast agent. S. Richard, V. Eder, G.Caputo, C. Journé, P. Ou J. Bolley, L. Louedec, E. Guenin, L. Motte, N. Pinna, Y. Lalatonne, Nanomedecine,11 (21), 2769-2779, 2016.
[62] Massive Intracellular Biodegradation of Iron Oxide Nanoparticles Evidenced Magnetically at Single Endosome and Tissue Levels. F. Mazuel, A. Espinosa, N. Luciani, M. Reffay, R. Le Borgne, L. Motte, K. Desboeufs, A. Michel, T. Pellegrino , Y. Lalatonne , C. Wilhelm, ACS Nano, 10 (8), 7627–7638, 2016.
[61] Vectorization of Nucleic Acids for Therapeutic Approach: Tutorial Review. F. Geinguenaud, E. Guenin,Y. Lalatonne, L. Motte, ACS Chem. Biol., 11, 1180−1191, 2016
[60] Nanomedicine: Towards the “Magic Bullet” Science, F.Benyettou, L .Motte, J Bioanal. Biomed. 8: e137 editorial 2016.
[59]Chitosan/poly(γ-glutamic acid) polyelectrolyte complexes: from self-assembly to application in biomolecules delivery and regenerative medicine. Antunes, J. C., Gonçalves, R. M., Barbosa, M. A., Res Rev: J Mater Sci 4, 12, 2016.
[58] Magnetic nano-organocatalysts: impact of surface functionalization on catalytic activity. E. Nehlig, L. Motte and E. Guenin. RSC Adv., 5, 104688–104694, 2015
[57] Curcumin hormesis mediates a cross talk between autophagy and cell death, N Rainey, L Motte, BB Aggarwal , PX Petit, Cell Death and Disease 6, e2003; 2015.
[56] Iron oxide nanoparticles coated with a phosphorothioate oligonucleotide and a cationic peptide: exploring four different ways of surface functionalization. F. Geinguenaud, C. Banissi, A. Carpentier, L. Motte, Nanomaterials, Special Issue "Nanoparticles in Theranostics": article invite,5(4), 1588-1609; 2015.
[55] Synthesis of Silver Nanoparticles for the Dual Delivery of Alendronate and Doxorubicin to Cancer Cells, F. Benyettou, R. Rezgui, F. Ravaux, T. Jaber, K. Blumer, M. Jouiad, L. Motte, J-C. Olsen, C. Platas-Iglesias, M. Magzoub, A. Trabolsi; J. Mater. Chem. B, 3, 7237-7245, 2015.
[54] Silica-Coated and Bare Akaganeite Nanorods: Structural and Magnetic Properties; M. Tadic, I. Milosevic, S. Kralj , M. Mbodji , L. Motte, J. Phys. Chem. C, 119 (24), 13868–13875, 2015.
[53] Ferromagnetic behavior and exchange bias effect in akaganeite nanorods, M.Tadic, I. Milosevic, S. Kralj, M.L.Saboungi, L. Motte, Appl. Phys. Lett. 106, 183706, 2015.
[52] Non-Aqueous Sol–Gel Synthesis of Ultra Small Persistent Luminescence Nanoparticles for Near-Infrared In Vivo Imaging, S. Richard , E. Teston, ,T. Maldiney, N. Lièvre, G. Y. Wang, L. Motte, C. Richard, Y. Lalatonne, Chem. Eur. J. 21, (20), 7350–7354, 2015 Cover.
[51] Design, Properties and in vivo Behaviour of Superparamagnetic Persistent Luminescence Nanohybrids, E. Teston, Y. Lalatonne, D. Elgrabli, , G. Autret, , L. Motte, F. Gazeau, D. Scherman,O. Clément, C. Richard, T. Maldiney, Small, 11, (22), 2696–2704, 2015.
[50] Magnetosomes, Biogenic Magnetic Nanomaterials for Brain Molecular Imaging with 17.2 T MRI Scanner, S. Mériaux, M. Boucher, B. Marty, Y. Lalatonne, S. Préveral, L. Motte, C. T. Lefèvre, F. Geffroy, F. Lethimonnier, M. Péan, D. Garcia, G. Adryanczyk-Perrier, D.Pignol , N. Ginet , Adv. Healthc. Mater. 4(7), 1076-1083, 2015.
[49] Endothelin B receptors targeted by iron oxide nanoparticles functionalized with a specific antibody: toward immunoimaging of brain tumors. S. Richard, M. Boucher, A. Herbet, Y. Lalatonne, S. Meriaux, D. Boquet, L. Motte, J . Mater. Chem. B, 3, 2939-2942, 2015.
[48] Dextrin-based nanomagnetogel: in vivo biodistribution and stability. C. Gonçalves , J. Pedro Silva, I. F. Antunes , M. F. Ferreira , J. A. Martins , C.s F.G.C. Geraldes , Y. Lalatonne, L. Motte , E. De Vries, F. M.l Gama, Bioconjug. Chem. 26(4):699-706, 2015.
[47] Immobilized Pd on magnetic nanoparticles bearing proline as highly efficient and retrievable Suzuki- Miyaura catalyst in aqueous media. E. Nehlig, B. Waggeh, N. Millot, Y. Lalatonne, L. Motte, E Guénin, Dalton. Trans, 44 (2), 501 – 505, 2015
[46] SiO2 versus chelating agent@ iron oxide nanoparticles:interactions effect in nanoparticles assemblies at low magnetic field, C. de Montferrand, L. Hu, Y. Lalatonne, N. Lievre, D. Bonnin, A. Brioude, L. Motte, J. Sol-Gel Sci. Technol. 73, (3), 572-579, 2015
[45] In silico studies, synthesis and binding evaluation of substituted 2-pyrrolidinones as peptidomimetics of RGD tripeptide sequence, V.Toum , J. Bolley , Y. Lalatonne , C. Barbey, L. Motte , M. Lecouvey, J. Royer, N. Dupont , J.Perard-Viret, Eur. J. Med. Chem. 26;(93),360-72, 2015.
[44] Viologen-Templated Arrays of Cucurbit[7]uril-Modified Iron-Oxide Nanoparticles F. Benyettou, K.Nchimi-Nono, M. Jouiad, Y. Lalatonne, I. Milosevic, L.Motte, J.-C.Olsen, Na.Saleh, A.Trabolsi, Chem. Eur. J. 21, 4607-4613, 2015 Cover.
[43] An Interferon-γ-delivery system based on chitosan/poly(γ-glutamic acid) polyelectrolyte complexes modulates macrophage-derived stimulation of cancer cell invasion in vitro. Cardoso, A. P., Gonçalves, R. M., Antunes, J. C., Pinto, M. L., Pinto, A. T., Castro, F., Monteiro, C., Barbosa, M. A., Oliveira, M. J., Acta Biomater. 1, 157, 2015.
[42] Poly(γ-glutamic acid) as an exogenous promoter of chondrogenic differentiation of human mesenchymal stem/stromal cells. Antunes, J. C., Tsaryk, R., Gonçalves, R. M., Pereira, C. L., Landes, C., Brochhausen, C., Ghanaati, S., Barbosa, M. A., and Kirkpatrick, C. J., Tissue Eng. Part A 21, 1869, 2015.
[41] Easily Controlled Grafting of Oligonucleotides on Fe2O3 Nanoparticles: Physico-Chemical Characterization of DNA Organization and Biological Activity Studies. F. Geinguenaud, I. Souissi, R.Fagard, Y. Lalatonne, L. Motte, J. Phys Chem. B 1535-1544, 2014 .
[40] In vivo dextrin nanomagnetogel performance as dual imaging bioprobe. IF Antunes, C Goncalves, JP Silva, MFA Ferreira, JA Martins, C Geraldes, Y Lalatonne, L Motte, EFJ de Vries, FM Gama, European Journal of Nuclear Medicine And Molecular imaging 41, S414-S414, 2014.
[39] Catechol vs bisphosphonate ligand exchange at the surface of iron oxide nanoparticles: towards multi-functionalization. E. Guénin, Y. Lalatonne, J. Boley, I. Milosevic, C. Platas-Iglesias, L. Motte, J. Nanopart. Res. 16 (11), 2596, 2014.
[38] One pot microwave assisted synthesis of bisphosphonate alkene capped gold nanoparticles. R. Aufaure, Y. Lalatonne, O. Heintz, N. Liévre, L. Motte, E. Guénin, RSC Adv. 4 (103), 59315 – 59322, 2014
[37] Magnetic metrology for iron oxide nanoparticle scaled-up synthesis. I. Milosevic, F. Warmont, Y. Lalatonne, L. Motte RSC Adv., 4, 49086, 2014
[36] Nano-organocatalysts synthesis: Boc vs Fmoc protection. E. Nehlig, L. Motte, E. Guénin Catal. Today, 90-96, 2013.
[35] Microwave assisted Functionalization of Materials: from the mesoscale to the nanoscale. E. Nehlig I. Milosevic, L. Motte, E. Guénin, Curr. Org. Chem. 17 (5) 528-544, 2013.
[34] Ultra-small superparamagnetic iron oxide nanoparticles made to order. F. Benyettou, I. Milosevic, JC Olsen, L Motte, A.Trabolsi, J. Bioanal. Biomed. S5:006. doi:10.4172/1948-593X.S5-006 2013.
[33] Iron oxide nanoparticles with sizes, shapes and compositions resulting in different magnetization signatures as potential labels for multiparametric detection. C. de Montferrand, L. Hu, I. Milosevic, V. Russier, D. Bonnin, L. Motte, A. Brioude, Y. Lalatonne, Acta Biomaterialia 9, 6150–6157, 2013
[32] Nanoparticles under the light: click functionalization by photochemical thiol-yne reaction, towards double click functionalization. P. Demay Drouhard, E. Nehlig, J. Hardouin, L. Motte, E. Guénin, Chem. Eur. J. 19, 8388-8392, 2013.
[31] Magnetization of densely packed interacting magnetic nanoparticles with cubic and uniaxial anisotropies: A Monte Carlo study. V. Russier, C. de-Montferrand, Y. Lalatonne, L. Motte, J. Appl. Phys. 114, 143904, 2013.
[30] New dextrin nanomagnetogels as contrast agents for magnetic resonance imaging. C. Gonçalves, Y. Lalatonne, L. Melro, G. Badino, M. F. M. Ferreira, L. David, C. F. G. C. Geraldes, L. Motte, J. A. Martins, F. M. Gama J. Mater. Chem. B, 1, 5853-58640, 2013.
[29] Toward theranostic nanoparticles: CB[7]-functionalized iron oxide for drug delivery and MRI . F. Benyettou, I. Milosevic, Y.Lalatonne, F. Warmont, R. Assah, J.-C. Olsen, M. Jouaid, L. Motte, C. Platas-Iglesias, A. Trabolsi J. Mater. Chem. B 1, 5076-5082, 2013.
[28] Optimized Multimodal Nanoplatform for targeting αvβ3 integrins, J. Bolley, Y. Lalatonne, O. Haddad, D. Letourneur, M. Soussan, J. Perard-Viret, L. Motte, Nanoscale 7;5(23):11478-89, 2013.
[27] Carbodiimide versus Click chemistry for nanoparticle surfacefunctionalization: a comparative study for the elaboration of multimodal superparamagnetic Nanoparticles targeting αvβ3integrins. J. Bolley, E. Guénin, N. Lievre, M. Lecouvey, M. Soussan, Y. Lalatonne, L. Motte, Langmuir, 29 (47), 14639–14647, 2013. Article highlighted in 2015 ACS Select Virtual Issue: Creating and Controlling Biointerfaces.
[26] Effect of Cobalt Doping Concentration on the Crystalline Structure and Magnetic Properties of Monodisperse CoxFe3-XO4 Nanoparticles Within Non-Polar and Aqueous Solvent, L. Hu, C. De Montferrand, Y. Lalatonne, L. Motte, A. Brioude, J. Phys. Chem. C, 116 (7), 4349–4355, 2012.
[25] Electrostatic Assembly of a DNA Superparamagnetic Nanotool for Simultaneous Intracellular Delivery and In-Situ Monitoring, F. Geinguenaud, I. Souissi, R. Fagard, L. Motte, Y. Lalatonne, Nanomed. Nanotechnol. Biology and Medicine, 8 (7): 1106-15, 2012.
[24] Size-dependent non linear weak-field magnetic behavior of maghemite nanoparticles , C. de Montferrand, Y. Lalatonne, D. Bonnin, N. Lièvre, M. Lecouvey, P. Monod, V. Russier, L. Motte, Small, 8, (12), 1945–1956, 2012.
[23] Non linear magnetic behavior around zero field of an assembly of superparamagnetic nanoparticles. C. de Montferrand, Y. Lalatonne, D. Bonnin, L. Motte, P. Monod, Analyst 137, 2304-2308, 2012.
[22] Reversible multi polyelectrolyte layers on gold nanoparticles. DD Lekeufack, A Brioude, Y Lalatonne, L Motte, AW Coleman, P Miele, J. Nanoparticle Research 14 (6), 1-7, 2012
[21] Bivalent alkyne-bisphosphonate as clickable and solid anchor to elaborate multifunctional iron oxide nanoparticles with microwave enhancement, E. Guénin, J. Hardouin, Y. Lalatonne, L. Motte, J. Nanopart. Res. 14, (7), 965-975, 2012.
[20] Size and polydispersity effect on the magnetization of densely packed magnetic nanoparticles V. Russier, C. de Montferrand, Y. Lalatonne, L. Motte J. Appl. Phys. 112, 073926, 2012.
[19] What are the Current Advances Regarding Iron Oxide Nanoparticles for Nanomedicine ? Editorial L. Motte J. Bioanal. Biomed., 4,39-45, 2012.
[18] PEGylated Versus Non-PEGylated γ Fe2O3@Alendronate Nanoparticles. F. Benyettou, J. Hardouin, M. Lecouvey, H. Jouni, L. Motte, J. Bioanal. Biomed. 4: 039-045, 2012.
[17]Mesenchymal Stem Cell Recruitment by Stromal Derived Factor-1-Delivery Systems Based on Chitosan/Poly(Gamma-Glutamic Acid) Polyelectrolyte Complexes. Gonçalves, R. M., Antunes, J. C., Barbosa, M. A., Eur. Cells Mater. 23, 249, 2012.
[16] Biosynthesis of highly pure poly-gamma-glutamic acid for biomedical applications. Pereira, C. L., Antunes, J. C., Goncalves, R. M., Ferreira-da-Silva, F., Barbosa, M. A., J. Mater. Sci. Mat. Med. 23, 1583, 2012.
[15] Multimodal superparamagnetic nanoplatform for clinical applications: immunoassays, imaging & therapy. L. Motte, F. Benyettou, C. de Beaucorps, M. Lecouvey, I. Milosevic, Y.Lalatonne, Faraday Discuss., 149, 211-225, 2011.
[14] Microwave Assisted Nanoparticle Surface Functionalization. F. Benyettou, E. Guenin, Y. Lalatonne, L. Motte Nanotechnology, 22(5):055102 2011 .
[13] Multimodal Magnetic Resonance Imaging Nanoplatform for Cancer Theranostics, F. Benyettou, Y.Lalatonne, I.Chebbi, M. Di Benedetto, J. M.Serfaty, M. Lecouvey, L. Motte
Phys. Chem. Chem. Phys., 12, 2735-40, 2011.
[12] Magnetoliposome for Alendronate Delivery. F. Benyettou, I. Chebbi, L. Motte, O. Seksek J. Mater. Chem., 4813-4820, 2011.
[11] Facile Microwave Process in Water for the Fabrication of Magnetic Nanorods, I. Milosevic , H. Jouni, C. David, F. Warmont, D. Bonnin, L. Motte, J. Phys. Chem. C, 115 (39), 18999–19004, 2011.
[10] An innovative nanoprobe for magnetic immunoassay: individual -Fe2O3 nanoparticles; towards high sensitive and multiparametric detection, C. de Montferrand, I. Milosevic, H. Jouni, N. Lièvre, Y. Lalatonne, L. Motte, IRBM, 32 (5), 302-305, 2011.
[9] Layer-by-layer self-assembly of Chitosan and Poly(gamma-glutamic acid) into polyelectrolyte complexes. Antunes, J. C., Pereira, C. L., Molinos M., Ferreira da Silva, F., Dessí, M., Gloria, A., Ambrosio, L., Gonçalves, R. M., Barbosa, M. A., Biomacromolecules 12, 4183, 2011.
[8] Three-dimensional scaffolds as a model system for neural and endothelial 'in vitro' culture, Veiga, D. D., Antunes, J. C., Gómez, R. G., Mano, J. F., Gómez-Ribelles, J. L., Soria, J. M., J. Biomater. Appl. 26, 293, 2011.
[7] Superparamagnetic Bifunctional Bisphosphonates Nanoparticles: a Potential MRI Contrast Agent for Osteoporosis. Y. Lalatonne, M. Monteil, H. Jouni, J.M. Serfaty, O. Sainte-Catherine, N. Lièvre, S. Kusmia, P. Weinmann, M. Lecouvey, L. Motte, J. Osteoporosis, Article ID 747852, doi:10.4061/2010/747852, 2010.
[6] Elaboration and characterization of magnetic nanocomposite fibers by electrospinning. V. Salles, A. Brioude, Y.Lalatonne, L. Motte, P. Monod, D. Cornu ;P. Miele J. Nanopart. Res. 12, 2735-40, 2010.
[5] Different signatures between chemically and biologically synthesized nanoparticles in a magnetic sensor: A new technology for multiparametric detection E. Alphandéry, L. Lijeour, Y. Lalatonne, L. Motte Sensors Actuat. B, 147, 786–790, 2010.
[4]Novel poly(L-lactic acid)/hyaluronic acid macroporous hybrid scaffolds: characterization and assessment of cytotoxicity. Antunes, J. C., Oliveira, J. M., Reis, R. L., Soria, J. M., Gómez-Ribelles, J. L. and Mano, J. F., J. Biomed. Mater. Res. A 94A, 856, 2010.
[3] Superparamagnetic nanovector with anti-cancer properties: Fe2O3@Zoledronate. F. Benyettou, Y. Lalatonne, O. Sainte-Catherine, M. Monteil, L. Motte. Int. J. Pharm., 379, 324-327, 2009.
[2] Characterization of magnetic labels for bioassays, Y. Lalatonne, F. Benyettou, D. Bonnin, N. Lièvre, P. Monod, M. Lecouvey; P. Weinmann, L. Motte. J. Mag. Mag. Mater. 321, (10) 1653-1657 2009.
[1] Bis-Phosphonates Ultra Small Superparamagnetic Iron Oxide Nanoparticles: A Platform Towards Diagnosis and Therapy; Y.Lalatonne, C. Paris,J .M. Serfatty, P. Weinmann, M. Lecouvey and L. Motte Chem. Comm., 2553-2555, 2008.